Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis

Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis

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Background/AimsThe long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with thiopurine are unclear.The aim of this study was to assess the long-term efficacy and safety of maintenance treatment with thiopurine sten jacket m in UC patients.MethodsThis was a retrospective observational cohort analysis conducted at a single center.

Between December 1998 and August 2013, 59 of 87 patients with bio-naive UC who achieved remission after induction with treatments other than biologics were enrolled.Remission maintenance with thiopurine was defined as no concomitant treatment needed other than 5-aminosalicylate without relapse.We assessed the remission-maintenance rate, mucosal healing rate, colectomy-free rate, and treatment safety in UC patients who received thiopurine as maintenance treatment.

ResultsThe 84-month cumulative remission-maintenance and colectomy-free survival rates in the UC patients who were receiving maintenance treatment with thiopurine and 5-aminosalicylate were 43.9% and 88.0%, respectively.

Of the 38 iphone 13 pro max price florida patients who underwent colonoscopy during thiopurine maintenance treatment, 23 (60.5%) achieved mucosal healing.Of the 59 patients who achieved clinical remission with thiopurine, 6 patients (10.

2%) discontinued the thiopurine therapy because of adverse events.ConclusionsOur study demonstrates the long-term efficacy and safety of thiopurine treatment in patients with bio-naive UC.